1. Langley J, Huddleston DE, Hu X. Nigral diffusivity, but not free water, correlates with iron content in Parkinson’s disease. Brain Communications. (In press).


2. Langley J, Hussain S, Huddleston D, Bennett I, and Hu X. Impact of locus coeruleus and its projections on memory and aging. Brain Connectivity. (2021) Jun 17. PMID: 34139886. doi:10.1089/brain.2020.0947


3. Hackney ME, Bay AA, Jackson JM, Nocera J, Krishnamurthy V​, Evatt ML, Langley J, Cui X, McKay JL, Huddleston DERationale and Design of the PAIRED Trial: Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease. Front Neurol. (2020) Oct 9;11:943. doi:10.3389/fneur.2020.00943

4. Langley J, Huddleston DE, Crosson B, Song DD, Factor SA, Hu X. Multimodal assessment of nigrosomal degeneration in Parkinson's disease. Parkinsonism & Related Disorders. (2020) Sep;80:102-107. doi: 10.1016/j.parkreldis.2020.09.021

5. He N, Langley J, Huddleston DE, Chen S, Huang P, Ling H, Yan F, Hu X. Increased iron-deposition in lateral-ventral substantia nigra pars-compacta: A promising neuroimaging marker for Parkinson's disease. NeuroImage: Clinical. (2020) Aug; 28. doi: 10.1016/j.nicl.2020/102391​

6. Catanzaro JN, Chan N, Ismail H, Huddleston D, Makaryus AN, Makaryus JN. Proarrhythmic Manifestations of Neuromuscular Dystrophinopathies. Cardiology in Review. (2020) Feb 14. doi:10.1097/CRD.0000000000000305


7. Peterson B, Armstrong M, Galasko D, Galvin JE, Goldman J, Irwin D, Paulson H, Kaufer D, Leverenz J, Lunde A, McKeith IG, Siderowf A, Taylor A, Amodeo K, Barrett M, Domoto-Reilly K, Duda J, Gomperts S, Graff-Radford N, Holden S, Honig L, Huddleston D, Lippa C, Litvan I, Manning C, Marder K, Moussa C, Onyike C, Pagan F, Pantelyat A, Pelak V, Poston K, Quinn J, Richard I, Rosenthal LS, Sabbagh M, Scharre D, Sha S, Shill H, Torres-Yaghi Y, Christie T, Graham T, Richards I, Koehler M, Boeve B. Lewy Body Dementia Association's Research Centers of Excellence Program: Inaugural Meeting Proceedings. Alzheimer's Research & Therapy. (2019) March 13;11(1):23. doi: 10.1186/s13195-019-0476-1


8. Ellis CA, Gu P, Sendi SE, Huddleston D, Sharma A, Mahmoudi B. A Cloud-based Framework for Implementing Portable Machine Learning Pipelines for Neural Data analysis. IEEE Engineering in Medicine & Biology Society 2019. Berlin, Germany. Peer Reviewed Conference Paper, Oral Presentation 7/26/2019. doi: 10.1109/EMBC.2019.8856929


9. Langley J*, He N*, Huddleston DE*, Chen S, Yan F, Crosson B, Factor S, Hu X. Reproducible detection of nigral iron deposition in 2 Parkinson’s disease cohorts. Movement Disorders. (2019) March;34(3):416-419. *equal contributions--shared first-authorship. doi: 10.1002/mds.27608.

10. Huddleston DE, Langley J, Dusek P, He N, Faraco CC, Crosson B, Factor S, Hu X. Imaging parkinsonian pathology in substantia nigra with MRI. Current Radiology Reports. (2018) April; 6(4):15.

doi: 10.1007/s40134-018-0272-x


11. He N, Langley J, Huddleston DE, Ling H, Xu H, Liu C, Yan F, Hu XP. Improved Neuroimaging Atlas of the Dentate Nucleus. Cerebellum. (2017) July 1; 16: 951-956. doi: 10.1007/s12311-017-0872-7


12. Huddleston DE, Langley J, Sedlacik J, Boelmans K, Factor SA, Hu XP. In vivo detection of lateral-ventral tier nigral degeneration in Parkinson’s disease. Human Brain Mapping. (2017) May; 38(5):2627-2634. doi: 10.1002/hbm.23547


13. Langley J, Huddleston DE, Liu CJ, Hu X. Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI. MAGMA. (2017) Apr;30(2):121-25. 2016. PMID: 27687624.

doi: 10.1007/s10334-016-0590-z


14. Langley J, Huddleston DE, Sedlacik J, Boelmans K, Hu XP. Parkinson’s disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta. Movement Disorders. (2017) Mar;32(3):441-49. doi: 10.1002/mds.26883


15. Langley J, Huddleston DE, Merritt M, Chen X, McMurray R, Silver M, Factor SA, Hu X. Diffusion tensor imaging of the substantia nigra in Parkinson’s disease revisited. Human Brain Mapping. (2016) Jul;37(7):2547-56. doi: 10.1002/hbm.23192


16. Bowman FD, Drake DF, Huddleston DE. Multimodal Imaging Signatures of Parkinson’s Disease. Frontiers in Neuroscience. (2016) Apr 18;10:131. eCollection 2016. PMID: 27147942. 

doi: 10.3389/fnins.2016.00131


17. Langley J, Huddleston DE, Chen X, Sedlacik J, Zachariah N, Hu X. A multicontrast approach for comprehensive imaging of substantia nigra. NeuroImage. (2015) May 15; 112:7-13. PMID: 25731994.

doi: 10.1016/j.neuroimage.2015.02.045


18. Chen X, Huddleston DE, Langley J, Ahn S, Barnum CJ, Factor SA, Levey AI, Hu X. Simultaneous Imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. Magn Reson Imaging. (2014) Dec; 32(10): 1301-6. PMID: 25086330. doi: 10.1016/j.mri.2014.07.003


19. Huddleston DE, Factor SA. Of Monkeys and Men: Analysis of the Phase 2 Double-Blind, Sham-Surgery Controlled, Randomized Trial of AAV2-Neurturin Gene Therapy for Parkinson’s Disease. Curr Neurol Neurosci Rep. 2011 Aug: 11(4):345-348. PMID: 21505812. doi: 10.1007/s11910-011-0206-y


20. Fernandez A, Schmidt JM, Claassen J, Pavlicova M, Huddleston D, Kreiter KT, Ostapkovich ND, Kowalski RG, Parra A, Connolly ES, Mayer SA. Fever after subarachnoid hemorrhage: risk factors and impact on outcome. Neurology. (2007) Mar 27;(68)13:1013-19. PMID: 17314332.

doi: 10.1212/01.wnl.0000258543.45879.f5


21. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. (2007) Mar 27;104(13):5638-43. PMID: 17374720. doi: 10.1073/pnas.0611721104


22. Huddleston DE, Small SA. Technology Insight: imaging amyloid plaques in the living brain with positron emission tomography and MRI. Nature Clinical Practice Neurology. 2005; 1(2): 96-105. PMID: 16932505. doi: 10.1038/ncpneuro0046