SELECTED PUBLICATIONS
1. Choudhury, P, Lee-Iannotti JK, Busicescu AO, Rangan R, Fantini ML, Avidan AY, Bliwise DL, Criswell SR, During Eh, Elliot JE, Field JA, Forsberg LK, Gagnon JF, Howell MJ, Huddleston DE, McLeland J, Mignot E, Lim MM, Schenck CH, Shprecher DR, St. Louis EK, Videnovic A, Ju Y, Boeve BF, Postuma R, NAPS Consortium. Development and validation of the RBD Symptom Severity Scale (RBDSS) in participants of the North American Prodromal Synucleinopathy (NAPS) Consortium. Neurology. Accepted 9/18/2023.
2. Elliot JE, Keil AT, Bryant-Ekstrand, M, Ligman, BR, Lim MM, Zitser J, During EH, Postuma RB, Pelletier A, Gagnon JF, St. Louis EK, David AA, Forsbery LK, Fields JA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, Criswell SR, Videnovic A, Lee-Iannotti JK, Boeve BF, Ju Y, Miglis MG, NAPS Consortium. Frequency of Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder: The North American Prodromal Synucleinopathy Cohort. Neurology. Accepted 7/13/2023.
3. Huddleston DE, Chen X, Hwang KS, Langley J, Tripathi R, Tucker K, McKay JL, Hu XP, Factor SA. Neuromelanin-sensitive MRI correlates of cognition, motor function, and aging in Parkinson's disease with freezing of gait. Frontiers Dementia. 2023 Aug 11;2. doi: 10.3389/frdem.2023.1215505
4. Hwang KS, Langley J, Tripathi R, Hu XP, Huddleston DE. In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson’s disease using neuromelanin-sensitive MRI: replication in two cohorts. PLoS One. 2023 Apr 13;18(4):e0282684. PMID: 37053195. doi: 10.1371/journal.pone.0282684.
5. Elliot JE, Lim MM, Avidan AY, Bliwise DL, Criswell SR, During EH, Fields JA, Forsberg LK, Gagnon JF, Howell MH, Huddleston DE, Keil AT, Lee-Iannotti JK, McLeland J, Miglis MG, Postuma RB, Schenck CH, Shprecher DR, St. Louis EK, Videnovic A, Boeve BF, Ju Y, NAPS Consortium. Baseline characteristics of the North American Prodromal Synucleinopathy Consortium cohort. Annals of Clinical and Translational Neurology. (2023) Feb 8. doi: 10.1002/acn3.51738
6. Langley J, Hwang KS, Hu XP, Huddleston DE. Nigral volumetric and microstructural measures in individuals with scans without evidence of dopaminergic deficit. Frontiers in Neuroscience. (2022) Nov 24; 16. doi: 10.3389/fnins.2022.1048945
7. Langley J, Hussain S, Huddleston D, Bennett I, and Hu X. Impact of locus coeruleus and its projections on memory and aging. Brain Connectivity. (2022) Apr 19; 12(3). doi:10.1089/brain.2020.0947
8. Scott G, Arnold M, Beach T, Gibbons C, Kanthasamy A, Lebovitz R, Lemstra A, Shaw L, Teunissen C, Zetterberg H, Taylor A, Graham T, Boeve B, Gomperts S, Graff-Radford N, Moussa C, Poston K, Rosenthal L, Sabbagh M, Walsh R, Weber M, Armstrong M, Bang J, Bozoki A, Domoto-Reilly K, Duda J, Fleisher J, Galasko D, Galvin J, Goldman J, Holden S, Honig L, Huddleston DE, Leverenz J, Litvan I, Manning C, Marder K, Pantelyat A, Pelak V, Scharre D, Sha S, Shill H, Zoltan M, Quinn J, Irwin D. Fluid and tissue biomarkers of Lewy body dementia: report of an LBDA symposium. Frontiers Neurology. (2022) Jan 13;12:805135. doi: 10.3389/fneur.2021.805135
9. Langley J, Huddleston DE, Hu X. Nigral diffusivity, but not free water, correlates with iron content in Parkinson’s disease. Brain Communications. (2021) Oct 23;3:4. doi:10.1093/braincomms/fcab251
10. Hackney ME, Bay AA, Jackson JM, Nocera J, Krishnamurthy V, Evatt ML, Langley J, Cui X, McKay JL, Huddleston DE. Rationale and Design of the PAIRED Trial: Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease. Front Neurol. (2020) Oct 9;11:943. doi:10.3389/fneur.2020.00943
11. Langley J, Huddleston DE, Crosson B, Song DD, Factor SA, Hu X. Multimodal assessment of nigrosomal degeneration in Parkinson's disease. Parkinsonism & Related Disorders. (2020) Sep;80:102-107. doi: 10.1016/j.parkreldis.2020.09.021
12. He N, Langley J, Huddleston DE, Chen S, Huang P, Ling H, Yan F, Hu X. Increased iron-deposition in lateral-ventral substantia nigra pars-compacta: A promising neuroimaging marker for Parkinson's disease. NeuroImage: Clinical. (2020) Aug; 28. doi: 10.1016/j.nicl.2020/102391
13. Catanzaro JN, Chan N, Ismail H, Huddleston D, Makaryus AN, Makaryus JN. Proarrhythmic Manifestations of Neuromuscular Dystrophinopathies. Cardiology in Review. (2020) Feb 14. doi:10.1097/CRD.0000000000000305
14. Peterson B, Armstrong M, Galasko D, Galvin JE, Goldman J, Irwin D, Paulson H, Kaufer D, Leverenz J, Lunde A, McKeith IG, Siderowf A, Taylor A, Amodeo K, Barrett M, Domoto-Reilly K, Duda J, Gomperts S, Graff-Radford N, Holden S, Honig L, Huddleston D, Lippa C, Litvan I, Manning C, Marder K, Moussa C, Onyike C, Pagan F, Pantelyat A, Pelak V, Poston K, Quinn J, Richard I, Rosenthal LS, Sabbagh M, Scharre D, Sha S, Shill H, Torres-Yaghi Y, Christie T, Graham T, Richards I, Koehler M, Boeve B. Lewy Body Dementia Association's Research Centers of Excellence Program: Inaugural Meeting Proceedings. Alzheimer's Research & Therapy. (2019) March 13;11(1):23. doi: 10.1186/s13195-019-0476-1
15. Ellis CA, Gu P, Sendi SE, Huddleston D, Sharma A, Mahmoudi B. A Cloud-based Framework for Implementing Portable Machine Learning Pipelines for Neural Data analysis. IEEE Engineering in Medicine & Biology Society 2019. Berlin, Germany. Peer Reviewed Conference Paper, Oral Presentation 7/26/2019. doi: 10.1109/EMBC.2019.8856929
16. Langley J*, He N*, Huddleston DE*, Chen S, Yan F, Crosson B, Factor S, Hu X. Reproducible detection of nigral iron deposition in 2 Parkinson’s disease cohorts. Movement Disorders. (2019) March;34(3):416-419. *equal contributions--shared first-authorship. doi: 10.1002/mds.27608.
17. Huddleston DE, Langley J, Dusek P, He N, Faraco CC, Crosson B, Factor S, Hu X. Imaging parkinsonian pathology in substantia nigra with MRI. Current Radiology Reports. (2018) April; 6(4):15.
doi: 10.1007/s40134-018-0272-x
18. He N, Langley J, Huddleston DE, Ling H, Xu H, Liu C, Yan F, Hu XP. Improved Neuroimaging Atlas of the Dentate Nucleus. Cerebellum. (2017) July 1; 16: 951-956. doi: 10.1007/s12311-017-0872-7
19. Huddleston DE, Langley J, Sedlacik J, Boelmans K, Factor SA, Hu XP. In vivo detection of lateral-ventral tier nigral degeneration in Parkinson’s disease. Human Brain Mapping. (2017) May; 38(5):2627-2634. doi: 10.1002/hbm.23547
20. Langley J, Huddleston DE, Liu CJ, Hu X. Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI. MAGMA. (2017) Apr;30(2):121-25. 2016. PMID: 27687624.
doi: 10.1007/s10334-016-0590-z
21. Langley J, Huddleston DE, Sedlacik J, Boelmans K, Hu XP. Parkinson’s disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta. Movement Disorders. (2017) Mar;32(3):441-49. doi: 10.1002/mds.26883
22. Langley J, Huddleston DE, Merritt M, Chen X, McMurray R, Silver M, Factor SA, Hu X. Diffusion tensor imaging of the substantia nigra in Parkinson’s disease revisited. Human Brain Mapping. (2016) Jul;37(7):2547-56. doi: 10.1002/hbm.23192
23. Bowman FD, Drake DF, Huddleston DE. Multimodal Imaging Signatures of Parkinson’s Disease. Frontiers in Neuroscience. (2016) Apr 18;10:131. eCollection 2016. PMID: 27147942.
24. Langley J, Huddleston DE, Chen X, Sedlacik J, Zachariah N, Hu X. A multicontrast approach for comprehensive imaging of substantia nigra. NeuroImage. (2015) May 15; 112:7-13. PMID: 25731994.
doi: 10.1016/j.neuroimage.2015.02.045
25. Chen X, Huddleston DE, Langley J, Ahn S, Barnum CJ, Factor SA, Levey AI, Hu X. Simultaneous Imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. Magn Reson Imaging. (2014) Dec; 32(10): 1301-6. PMID: 25086330. doi: 10.1016/j.mri.2014.07.003
26. Huddleston DE, Factor SA. Of Monkeys and Men: Analysis of the Phase 2 Double-Blind, Sham-Surgery Controlled, Randomized Trial of AAV2-Neurturin Gene Therapy for Parkinson’s Disease. Curr Neurol Neurosci Rep. 2011 Aug: 11(4):345-348. PMID: 21505812. doi: 10.1007/s11910-011-0206-y
27. Fernandez A, Schmidt JM, Claassen J, Pavlicova M, Huddleston D, Kreiter KT, Ostapkovich ND, Kowalski RG, Parra A, Connolly ES, Mayer SA. Fever after subarachnoid hemorrhage: risk factors and impact on outcome. Neurology. (2007) Mar 27;(68)13:1013-19. PMID: 17314332.
doi: 10.1212/01.wnl.0000258543.45879.f5
28. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. (2007) Mar 27;104(13):5638-43. PMID: 17374720. doi: 10.1073/pnas.0611721104
29. Huddleston DE, Small SA. Technology Insight: imaging amyloid plaques in the living brain with positron emission tomography and MRI. Nature Clinical Practice Neurology. 2005; 1(2): 96-105. PMID: 16932505. doi: 10.1038/ncpneuro0046